Social Determinants

TB or not TB: What is Tuberculosis? Challenging the Current Paradigm of Tuberculosis Natural History using Mathematical Modelling Techniques

Aims: The current paradigm of TB natural history follows a basic set of rules devised 30 years ago. While attractive in their simplicity, it has become clear that these rules and the resulting model of TB natural history do not fit with new empirical insights from basic science on our understanding of TB epidemiology and its control. In the first stage tHis project will develop and explore a new model representation of TB natural history, In the second stage, we will use the model to explore critical questions in two areas of TB research that are likely to benefit from a fresh perspective on TB: the challenge of addressing latent tuberculosis infection; and incorporating the impact of changes in socio-economic indicators on TB trends.

People: Rein Houben

Funding: European Research Council Starting Grant


Controlling TB through action on its social and structural determinants: a modelling approach

Aims: Provide evidence on the impact of socio-economic determinants on TB control using mathematical modelling

People: Debora Pedrazzoli, Delia Boccia, Rein Houben, Richard White

Funding: Wellcome Trust, USAID, TB MAC


Nationwide patient cost survey in Ghana

Aims: To assess the financial burden of TB related costs on TB affected households in Ghana in collaboration with the Dodowa Health Research Centre and the Ghana National Tuberculosis Programme

People: Debora Pedrazzoli, Rein Houben, Delia Boccia, Samia Laokri, Knut Lönnroth, Andrew Siroka, Jo Borghi

Funding: USAID


Impact of a conditional cash transfer programme on HIV/AIDS and tuberculosis in Brazil and forecast of effectiveness scenarios

Aims: Estimate the impact of a conditional cash transfer programme on HIV/AIDS and tuberculosis in Brazil and forecast of effectiveness scenarios

People: Davide Rasella (Wellcome Trust), Rein Houben, Laura Rodrigues, Richard White, and colleagues

Funding: Wellcome Trust

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