TB-HIV

Stimulating and shaping the market for HIV self-testing in Africa: two-tier demonstration and evaluation of accuracy and linkage in 4 countries.

Aims: Stimulate and shape the market for HIV self-testing in Africa using data collection and modelling

People: Liz Corbett, Tom Sumner, Rein Houben, Andrew Philips (UCL), Richard White, and colleagues

Funding: UNITAID


Impact of a conditional cash transfer programme on HIV/AIDS and tuberculosis in Brazil and forecast of effectiveness scenarios

Aims: Estimate the impact of a conditional cash transfer programme on HIV/AIDS and Tuberculosis in Brazil and forecast of effectiveness scenarios

People: Davide Rasella (Wellcome Trust), Rein Houben, Laura Rodrigues, Richard White, and colleagues

Funding: Wellcome Trust


Potential impact of future TB vaccines in high HIV prevalent settings and aging populations

Aims: Estimate the epidemiological impact of potential TB vaccines in high burden settings with high HIV prevalence; Estimate the epidemiological impact of potential TB vaccines in high burden settings with ageing populations; Model outcomes can be used to prioritise development of vaccine candidates with greatest potential public health impact

People: Rebecca Harris, Tom Sumner, Gwen Knight (Imperial), Richard White, and colleagues

Funding: Medical Research Council


Closed projects

Consortium to respond effectively to the AIDS/TB epidemic (CREATE)

Aims: Reduce death and disease from TB in populations with high rates of HIV AIDS; 4 interventions: Zamstar: HH & ECF, Thibela TB: Mass IPT, DetecTB: ACF; Develop models that fit baseline populations; Gather data on key unknowns; Provide timely modelling, projection, and better understanding of trial results; Project longer term impact and alternative strategies

People: Liz Corbett, Richard White, Emilia Vynnycky, Richard Hayes, Dick Chaisson (JHU), Tom Sumner, Emilia Vynnycky, Pete Dodd (Sheffield)

Funding: Bill and Melinda Gates Foundation


Impact of IPT and ART on TB in South Africa

Aims: Provide evidence for policy making on how best to use IPT and ART to control TB in South Africa using mathematical modelling; Use empirical data to create model scenarios representing the diversity of TB/HIV epidemics in South Africa; Simulate range of scenarios of IPT and ART targeting and scale-up to estimate impact on MTB transmission and TB disease incidence; Provide setting-specific policy recommendations

People: Richard White, Emilia Vynnycky, Rein Houben, Katherine Fielding, Alison Grant, Taraz Samandari (CDC), Tom Sumner, Gwen Knight, Pete Dodd (Sheffield)

Funding: CDC/PEPFAR via Aurum Institute

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