Treatment

Interpreting the impact of mass community-wide isoniazid preventive treatment in Bethel, Alaska

Aims: Understand the reasons for the observed impact of preventive treatment in a high incidence setting in Alaska

People: Rein Houben, Emilia Vynnycky

Funding: none


 

Closed projects

Interpreting the outcome of the trial of mass community-wide preventive therapy in a high incidence setting in South Africa (Thibela TB)

Aims: Understand the reasons for the observed impact of mass community wide preventive treatment in a high incidence setting in South Africa

People: Richard White (PI on CREATE modelling core), Emilia Vynnycky, Tom Sumner, Alison Grant, Katherine Fielding, James Lewis, Andy Cox, Gavin Churchyard (Aurum Institute), Richard Hayes, Liz Corbett

Funding: Bill and Melinda Gates Foundation


Impact of IPT and ART on TB in South Africa

Aims: Provide evidence for policy making on how best to use IPT and ART to control TB in South Africa using mathematical modelling; Use empirical data to create model scenarios representing the diversity of TB/HIV epidemics in South Africa; Simulate range of scenarios of IPT and ART targeting and scale-up to estimate impact on MTB transmission and TB disease incidence; Provide setting-specific policy recommendations

People: Richard White, Emilia Vynnycky, Rein Houben, Katherine Fielding, Alison Grant, Taraz Samandari (CDC), Tom Sumner, Gwen Knight, Pete Dodd (Sheffield)

Funding: CDC/PEPFAR via Aurum Institute


VALUE-TB: Cost-effectiveness of two new shortened (4-MONTH) regimens (REMox)

Aims: Evaluate the cost-effectiveness of replacing standard regimens with a shortened REMox regimen that contain moxifloxacin instead of ethambutol or isoniazid

People: Anna Vassall, Gwen Knight, Richard White, Pete Dodd (Sheffield), Frank Cobelens (AIGHD), David Dowdy (JHSPH)

Funding: TB Alliance


Modelling impact for novel TB drug regimens

Aims: Investigate the impact and cost-effectiveness of difference drug susceptibility algorithms for new drug TB regimens

People: Gwen Knight, Richard White, David Dowdy (JHSPH), Ted Cohen (Harvard)

Funding: Bill and Melinda Gates Foundation

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