Treatment
Interpreting the impact of mass community-wide isoniazid preventive treatment in Bethel, Alaska
Aims: Understand the reasons for the observed impact of preventive treatment in a high incidence setting in Alaska
People: Rein Houben, Emilia Vynnycky
Funding: none
Closed projects
Interpreting the outcome of the trial of mass community-wide preventive therapy in a high incidence setting in South Africa (Thibela TB)
Aims: Understand the reasons for the observed impact of mass community wide preventive treatment in a high incidence setting in South Africa
People: Richard White (PI on CREATE modelling core), Emilia Vynnycky, Tom Sumner, Alison Grant, Katherine Fielding, James Lewis, Andy Cox, Gavin Churchyard (Aurum Institute), Richard Hayes, Liz Corbett
Funding: Bill and Melinda Gates Foundation
Impact of IPT and ART on TB in South Africa
Aims: Provide evidence for policy making on how best to use IPT and ART to control TB in South Africa using mathematical modelling; Use empirical data to create model scenarios representing the diversity of TB/HIV epidemics in South Africa; Simulate range of scenarios of IPT and ART targeting and scale-up to estimate impact on MTB transmission and TB disease incidence; Provide setting-specific policy recommendations
People: Richard White, Emilia Vynnycky, Rein Houben, Katherine Fielding, Alison Grant, Taraz Samandari (CDC), Tom Sumner, Gwen Knight, Pete Dodd (Sheffield)
Funding: CDC/PEPFAR via Aurum Institute
VALUE-TB: Cost-effectiveness of two new shortened (4-MONTH) regimens (REMox)
Aims: Evaluate the cost-effectiveness of replacing standard regimens with a shortened REMox regimen that contain moxifloxacin instead of ethambutol or isoniazid
People: Anna Vassall, Gwen Knight, Richard White, Pete Dodd (Sheffield), Frank Cobelens (AIGHD), David Dowdy (JHSPH)
Funding: TB Alliance
Modelling impact for novel TB drug regimens
Aims: Investigate the impact and cost-effectiveness of difference drug susceptibility algorithms for new drug TB regimens
People: Gwen Knight, Richard White, David Dowdy (JHSPH), Ted Cohen (Harvard)
Funding: Bill and Melinda Gates Foundation